{"id":9167,"date":"2019-10-28T19:14:22","date_gmt":"2019-10-28T19:14:22","guid":{"rendered":"http:\/\/cchc-herald.org\/eu\/?page_id=9167"},"modified":"2020-09-30T00:59:20","modified_gmt":"2020-09-30T00:59:20","slug":"%e5%b0%88%e9%a1%8c%ef%bc%9a-14","status":"publish","type":"page","link":"http:\/\/eu.cchc-herald.org\/?page_id=9167","title":{"rendered":"\u5c08\u984c\uff1a\u9732\u9732\u5a1c\u5a1c \u662f\u5426\u5b89\u597d\uff1f"},"content":{"rendered":"\n<p>2019\u5e7410\u6708 &nbsp;   <br> \u7b56\u5283\u8207\u64b0\u7a3f\uff1a\u6714\u65b9\u3001\u67ef\u6d25\u96f2\u3001\u5468\u5929\u99d2\u3001\u52de\u4f2f\u7965<\/p>\n\n\n\n<p>\u8b93\u8cc0\u5efa\u594e\u81ea\u8c6a\u4e0d\u5df2\u7684\u4e16\u754c\u7b2c\u4e00\u5275\u8209\u7a76\u7adf\u6709\u591a\u5192\u5931\uff0c\u9732\u9732\u5a1c\u5a1c\u4fbf\u6709\u591a\u7121\u8f9c\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u300c\u812b\u9776\u300d\u6548\u61c9<\/h2>\n\n\n\n<p>\u9019\u662f\u57fa\u56e0\u7de8\u8f2f\u4e2d\u6982\u7387\u975e\u5e38\u9ad8\u7684\u300c\u526f\u4f5c\u7528\u300d\uff1a\u9664\u4e86\u76ee\u6a19\u57fa\u56e0\u5916\uff0c\u5c0e\u81f4\u5176\u4ed6\u8207\u76ee\u6a19\u5e8f\u5217\u4e0d\u5339\u914d\u7684\u5e8f\u5217\u88ab\u932f\u8aa4\u5207\u5272\uff0c\u5f9e\u800c\u5f15\u767c\u7121\u6cd5\u9810\u77e5\u7684\u7a81\u8b8a\u3002\u96d6\u7136Cas9\u524d\u6240\u672a\u6709\u5730\u7cbe\u6e96\uff0c\u53ef\u8fa8\u8a8d23\u500b\u9e7c\u57fa\u5e8f\u5217\uff08Nucleobase\uff0c\u907a\u50b3\u5bc6\u78bc\u57fa\u672c\u55ae\u5143\uff09\uff0c\u4f46\u4eba\u9ad4\u57fa\u56e0\u7d44\u6709\u7d0430\u5104\u500b\u9e7c\u57fa\u5c0d\uff0cCas9\u8981\u627e\u5230\u6b63\u78ba\u7684\u5e8f\u5217\u8ac7\u4f55\u5bb9\u6613\uff01\u5373\u4f7f\u5728\u7406\u60f3\u72c0\u6cc1\u4e0b\uff0cCas9\u6e96\u78ba\u526a\u958b\u76ee\u6a19DNA\uff0c\u4f46\u7d30\u80de\u9858\u4e0d\u9858\u5c07\u6b63\u78baDNA\u7247\u6bb5\u63a5\u4e0a\u53bb\u5462\uff1f<br>\n\u5973\u5b30\u857e\u62c9\u5192\u96aa\u5be6\u65bd\u5be6\u9a57\u968e\u6bb5\u7684\u57fa\u56e0\u7642\u6cd5\uff0c\u662f\u56e0\u70ba\u9664\u6b64\u4ee5\u5916\u5225\u7121\u751f\u6a5f\u3002\u9732\u9732\u548c\u5a1c\u5a1c\u537b\u4e0d\u540c\uff0c\u65e2\u975e\u5fc5\u7136\u611f\u67d3\u611b\u6ecb\u75c5\uff08\u6bcd\u89aaHIV\u9670\u6027\uff09\uff0c\u4e5f\u7121\u7acb\u5373\u7684\u751f\u5b58\u5371\u96aa\uff0c\u800c\u4fee\u6539\u57fa\u56e0\u537b\u6709\u300c\u812b\u9776\u300d\u98a8\u96aa\uff01\u64da\u8cc0\u5efa\u594e\u81ea\u8ff0\u6aa2\u6e2c\u7d50\u679c\uff0c\u96d9\u80de\u80ce\u4e2d\u53ea\u4e00\u4f4d\u7684\u5169\u4efd\u76ee\u7684\u57fa\u56e0\u88ab\u6539\u8b8a\uff0c\u53e6\u4e00\u4f4d\u5247\u53ea\u6539\u4e86\u4e00\u4efd\u3002\u9019\u5c0d\u9732\u9732\u548c\u5a1c\u5a1c\u610f\u5473\u8457\u4ec0\u9ebc\uff1f\u6c92\u4eba\u53ef\u4ee5\u56de\u7b54\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u98a8\u96aa\u672a\u77e5<\/h2>\n\n\n\n<p>\u54e5\u672c\u54c8\u6839\u5927\u5b78\u4eba\u985e\u5b78\u6559\u6388Ayo Wahlberg\u8a8d\u70ba\uff0c\u76ee\u524d\u4eba\u985e\u57fa\u56e0\u7de8\u8f2f\u7684\u79d1\u5b78\u6c34\u5e73\u9084\u672a\u767c\u5c55\u5230\u9032\u884c\u690d\u5165\u80da\u80ce\u57fa\u56e0\u7de8\u8f2f\u7684\u5730\u6b65\u3002\u502b\u6566\u5927\u5b78\u4eba\u985e\u907a\u50b3\u5b78\u5bb6Yalda Jamshidi\u5247\u8868\u793a\uff0c\u91ab\u5b78\u754c\u5c0d\u65bc\u985e\u4f3c\u5be6\u9a57\u7522\u751f\u7684\u9577\u671f\u5f71\u97ff\u77e5\u4e4b\u751a\u5c11\uff0c\u793e\u6703\u61c9\u8a72\u4ed4\u7d30\u8003\u616e\u5982\u4f55\u627f\u64d4\u65b0\u7642\u6cd5\u5e36\u4f86\u7684\u98a8\u96aa\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u53ef\u80fd\u5f71\u97ff\u5f8c\u4ee3\u7684\u6cbb\u7642\u3002<br>\nCCR5\u57fa\u56e0\u96d6\u662fHIV\u611f\u67d3\u7d30\u80de\u7684\u53d7\u9ad4\uff08\u8def\u5f91\uff09\uff0c\u4f46\u5176\u651c\u5e36\u7684\u907a\u50b3\u6307\u4ee4\u53ef\u4f7f\u4eba\u985e\u62b5\u6297\u5176\u4ed6\u75c5\u6bd2\u611f\u67d3\uff0c\u5c24\u5176\u662f\u6d41\u611f\u3002\u300a\u8907\u96dc\u75be\u75c5\u907a\u50b3\u5b78(Genetics of Complex Disease)\u300b\u4e00\u66f8\u5373\u6307\u51fa\uff0cCCR5\u5728\u5c0d\u897f\u5c3c\u7f85\u6cb3\u75c5\u6bd2\u611f\u67d3\u7684\u514d\u75ab\u53cd\u61c9\u4e2d\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002<br>\n\u52a0\u5dde\u5927\u5b78\u4f2f\u514b\u5229\u5206\u6821\u7814\u7a76\u4e86\u82f1\u570b\u8fd141\u842c\u4eba\u7684\u6a23\u672c\uff0c\u5831\u544a\u767c\u8868\u5728\u300c\u81ea\u7136\u91ab\u5b78(Nature Medicine)\u300d\u671f\u520a\uff1a\u9ad4\u5167\u6709CCR5\u8b8a\u7570\u57fa\u56e0\u7684\u4eba\uff0c\u572878\u6b72\u524d\u6b7b\u4ea1\u7684\u53ef\u80fd\u6027\u9ad8\u65bc\u5e38\u4eba20\uff05\uff1b\u6b7b\u56e0\u5c31\u662f\u975e\u5e38\u5e73\u51e1\u7684\u611f\u5192\u985e\u75be\u75c5\uff0c\u53ef\u80fd\u5728\u611f\u67d3\u897f\u5c3c\u7f85\u6cb3\u75c5\u6bd2\u5f8c\u51fa\u73fe\u66f4\u56b4\u91cd\u7684\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u3002\u4e3b\u6301\u7814\u7a76\u7684Rasmus Nielsen\u6559\u6388\u8aaa\uff1a\u300c\u5982\u6b64\u7684\u57fa\u56e0\u6539\u8b8a\uff0c\u53ef\u80fd\u4e26\u4e0d\u662f\u4eba\u60f3\u8981\u7684\u3002\u300d<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6548\u679c\u672a\u660e<\/h2>\n\n\n\n<p>\u6709\u5c08\u5bb6\u5f62\u5bb9\uff0c\u901a\u904eCCR5\u57fa\u56e0\u7de8\u8f2f\u8b93\u9732\u9732\u5a1c\u5a1c\u514d\u75ab\u611b\u6ecb\u75c5\u7684\u505a\u6cd5\uff0c\u7121\u7570\u65bc\u300c\u5927\u7832\u6253\u9ebb\u96c0\u300d\u3002\u9996\u5148\uff0c\u9810\u9632HIV\u6709\u66f4\u7c21\u4fbf\u3001\u66f4\u5b89\u5168\u7684\u65b9\u5f0f\u3002\u611b\u6ecb\u75c5\u6297\u75c5\u6bd2\u85e5\u7269\u6cbb\u7642\u5341\u5206\u6210\u719f\uff0c\u75c5\u4eba\u6bcf\u5929\u50c5\u9700\u670d\u7528\u4e00\u7c92\u85e5\u7269\uff0c\u4fbf\u53ef\u4ee5\u628a\u75c5\u6bd2\u58d3\u5236\u5728\u6975\u4f4e\u6c34\u5e73\uff0c\u5ef6\u9577\u58fd\u547d\u905450\u5e74\u3002\u502b\u6566\u5e1d\u570b\u5b78\u9662\u5e79\u7d30\u80de\u7814\u7a76\u5c08\u5bb6Dusko Ilic\u4e5f\u8868\u793a\uff0c\u5982\u679c\u611b\u6ecb\u75c5\u60a3\u8005\u4ee5\u85e5\u7269\u63a7\u5236\u75c5\u60c5\uff0c\u5e7e\u4e4e\u4e0d\u53ef\u80fd\u6703\u628a\u75c5\u6bd2\u50b3\u67d3\u7d66\u4e0b\u4e00\u4ee3\u3002<br>\n\u5176\u6b21\uff0c\u7528CRISPR\/Cas9\u6280\u8853\u8b8a\u7570CCR5\u57fa\u56e0\uff0c\u662f\u8b93\u514d\u75ab\u7d30\u80de\u62ab\u4e0a\u300c\u96b1\u8eab\u8863\u300d\uff0c\u4ee4\u75c5\u6bd2\u7121\u6cd5\u627e\u5230\u653b\u64ca\u76ee\u6a19\uff0c\u4e5f\u5c31\u4e0d\u80fd\u4fb5\u5165\u7d30\u80de\u589e\u6b96\uff0c\u6700\u7d42\u53cd\u88ab\u4eba\u9ad4\u5fb9\u5e95\u6e05\u9664\u2026\u2026\u4f46\u662f\uff0c\u4eba\u70ba\u8b8a\u7570\u7684CCR5\u57fa\u56e0\uff0c\u8207\u6cbb\u7652\u4e86\u300c\u67cf\u6797\u75c5\u4eba\u300d\u7684\u81ea\u7136\u57fa\u56e0\u7f3a\u9677CCR5-\u039432\uff0c\u662f\u5426\u529f\u6548\u76f8\u540c\u537b\u4ecd\u662f\u672a\u77e5\u6578\u3002<br>\n\u518d\u8005\uff0cCCR5\u53ea\u662fR5\u578bHIV\u75c5\u6bd2\u7684\u53d7\u9ad4\u86cb\u767d\uff1bHIV\u75c5\u6bd2\u9084\u6709X4\u578b\uff0c\u6240\u5c0d\u61c9\u7684\u611f\u67d3\u8def\u5f91\u662fCXCR4\u53d7\u9ad4\u86cb\u767d\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u5373\u4f7f\u9732\u9732\u548c\u5a1c\u5a1c\u7684CCR5\u57fa\u56e0\u7de8\u8f2f\u5b8c\u5168\u6210\u529f\uff0c\u4e5f\u53ea\u514d\u75ab\u4f86\u81eaR5\u7684\u611f\u67d3\uff0c\u5c0dX4\u7684\u5165\u4fb5\u4ecd\u7121\u80fd\u70ba\u529b\uff01\u5f9e\u9019\u500b\u610f\u7fa9\u4e0a\u8aaa\uff0c\u5979\u5011\u4e26\u4e0d\u662f\u771f\u6b63\u7684\u611b\u6ecb\u75c5\u5b8c\u5168\u514d\u75ab\u8005\u3002<br>\n\u9732\u9732\u548c\u5a1c\u5a1c\u7684\u7236\u6bcd\u53ef\u77e5\u4ed6\u5011\u7684\u6c7a\u5b9a\uff0c\u5c07\u8b93\u5b69\u5b50\u64d4\u7576\u4e86\u591a\u9ebc\u5927\u7684\u5065\u5eb7\u4e43\u81f3\u751f\u547d\u98a8\u96aa\uff1f<br>\n\u4eba\u985e\u7684\u72c2\u5984\uff0c\u662f\u5728\u5fae\u4e0d\u8db3\u9053\u7684\u300c\u767c\u73fe\u300d\u9762\u524d\u5f97\u610f\u5fd8\u5f62\uff0c\u4ee5\u70ba\u81ea\u5df1\u7d42\u53ef\u66ff\u4ee3\u9020\u7269\u4e3b\uff0c\u537b\u4e0d\u77e5\u8b93\u81ea\u5df1\u9a30\u96f2\u99d5\u9727\u7684\u53ea\u662f\u5df4\u5225\u5854\uff08\u5984\u60f3\u901a\u5929\u7684\u4eba\u9020\u5854\uff09\u800c\u5df2\u3002<\/p>\n\n\n<div id=\"nav_menu-20\" class=\"widget widget_nav_menu amr_widget\"><h4>2019\u5e7410\u6708\u5c08\u984c<\/h4><div class=\"menu-2019%e5%b9%b410%e6%9c%88%e5%85%a7%e5%ae%b9-container\"><ul id=\"menu-2019%e5%b9%b410%e6%9c%88%e5%85%a7%e5%ae%b9\" class=\"menu\"><li id=\"menu-item-9185\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9185\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9164\">\u5c08\u984c\uff1a(\u793e\u8ad6) \u667a\u6167\u7684\u5236\u7d04<\/a><\/li>\n<li id=\"menu-item-9179\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9179\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9169\">\u5c08\u984c\uff1a\u4e0a\u5e1d\u4e4b\u624b<\/a><\/li>\n<li id=\"menu-item-9180\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9180\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9168\">\u5c08\u984c\uff1a\u5169\u500b\u7b2c\u4e00\u4f8b \u53cd\u97ff\u96f2\u8207\u6ce5<\/a><\/li>\n<li id=\"menu-item-9181\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9181\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9167\">\u5c08\u984c\uff1a\u9732\u9732\u5a1c\u5a1c \u662f\u5426\u5b89\u597d\uff1f<\/a><\/li>\n<li id=\"menu-item-9182\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9182\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9166\">\u5c08\u984c\uff1a\u8ab0\u662f\u751f\u547d\u8a2d\u8a08\u8005\uff1f<\/a><\/li>\n<li id=\"menu-item-9183\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9183\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9163\">\u5c08\u984c\uff1a\u66f4\u9ad8\u7684\u610f\u5ff5<\/a><\/li>\n<li id=\"menu-item-9184\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9184\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9165\">\u65b0\u805e\u77ed\u8ad6\uff1a\u82f1\u570b\u721b\u5c3e\u6a13 \u812b\u6b50\u8b8a\u62d6\u6b50<\/a><\/li>\n<li id=\"menu-item-9199\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9199\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9195\">\u667a\u6167\u4e4b\u7a97: \u62c9\u93c8\u65b9\u7a0b\u5f0f<\/a><\/li>\n<li id=\"menu-item-9200\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9200\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9196\">\u667a\u6167\u4e4b\u7a97: \u611f\u6069\u8056\u5730\u904a<\/a><\/li>\n<li id=\"menu-item-9213\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9213\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9204\">\u751f\u547d\u7dda: \u8b93\u5c0f\u5b69\u5b50\u5230\u6211\u9019\u88e1\u4f86<\/a><\/li>\n<li id=\"menu-item-9214\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9214\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9205\">\u751f\u547d\u7dda: \u4e0a\u6d77Costco<\/a><\/li>\n<li id=\"menu-item-9215\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9215\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9206\">\u751f\u547d\u7dda: \u4fe1\u8036\u7a4c\u5f97\u6c34\u725b\uff1f<\/a><\/li>\n<li id=\"menu-item-9216\" class=\"menu-item menu-item-type-post_type menu-item-object-post menu-item-9216\"><a href=\"http:\/\/eu.cchc-herald.org\/?p=9208\">\u751f\u547d\u7dda: \u8056\u5f92\u76f8\u901a<\/a><\/li>\n<li id=\"menu-item-9234\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9234\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9226\">\u5929\u502b\u6a02: \u91cd\u8996\u81ea\u6211\u7167\u9867\u7684\u7236\u89aa<\/a><\/li>\n<li id=\"menu-item-9235\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9235\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9222\">\u5929\u502b\u6a02: \u5931\u6200\u4e2d\u7684\u795d\u798f<\/a><\/li>\n<li id=\"menu-item-9236\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9236\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9223\">\u5929\u502b\u6a02: \u5927\u5bb6\u5ead\u8207\u5c0f\u5bb6\u5ead<\/a><\/li>\n<li id=\"menu-item-9237\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9237\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9224\">\u5929\u502b\u6a02: \u6211\u5011\u7684\u5b69\u5b50<\/a><\/li>\n<li id=\"menu-item-9238\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9238\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9225\">\u5929\u502b\u6a02: \u300c\u958b\u5fc3\u300d\u8001\u7238<\/a><\/li>\n<li id=\"menu-item-9239\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9239\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9227\">\u5929\u502b\u6a02: \u627e\u5c0b\u4eba\u751f\u4f34\u4fb6<\/a><\/li>\n<li id=\"menu-item-9253\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9253\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9249\">\u7e7d\u7d1b\u4e16\u754c: \u89aa\u60c5\u651d\u5f71<\/a><\/li>\n<li id=\"menu-item-9254\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9254\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9247\">\u7e7d\u7d1b\u4e16\u754c: \u5feb\u5feb\u6a02\u6a02\u8b80\u4e00\u5e45\u756b<\/a><\/li>\n<li id=\"menu-item-9255\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9255\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9248\">\u7e7d\u7d1b\u4e16\u754c: \u7acb\u754c\u9650\u57f9\u990a\u54c1\u683c<\/a><\/li>\n<li id=\"menu-item-9270\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9270\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9262\">\u751f\u547d\u7684\u65cb\u5f8b: \u6b4c\u8072\u7559\u4f4f\u7684\u8001\u5abd\u5abd<\/a><\/li>\n<li id=\"menu-item-9271\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9271\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9263\">\u751f\u547d\u7684\u65cb\u5f8b: \u4e0a\u5e1d\u6492\u7a2e\u4e5f\u6f86\u704c<\/a><\/li>\n<li id=\"menu-item-9272\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9272\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9264\">\u751f\u547d\u7684\u65cb\u5f8b: \u795e\u7d66\u7684\u6bd4\u5931\u53bb\u7684\u591a<\/a><\/li>\n<li id=\"menu-item-9273\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9273\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9265\">\u751f\u547d\u7684\u65cb\u5f8b: \u66b4\u98a8\u5c11\u5973\u6d41\u6dda\u4e86<\/a><\/li>\n<li id=\"menu-item-9281\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9281\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9279\">\u751f\u547d\u7684\u65cb\u5f8b: \u54c8\u5229\u8def\u4e9e \u6012\u6c5f\u4e0a\u7a7a\u7684\u6b4c\u8072<\/a><\/li>\n<li id=\"menu-item-9285\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9285\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9283\">\u6559\u6703\u6d88\u606f: \u6b50\u6d32\u83ef\u4eba\u6559\u6703\u6982\u89bd \u6bd4\u5229\u6642(Belgium)<\/a><\/li>\n<li id=\"menu-item-9293\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9293\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9289\">\u904a\u5b50\u60c5: \u6708\u8272\u6eff\u7a97<\/a><\/li>\n<li id=\"menu-item-9294\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9294\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9287\">\u904a\u5b50\u60c5: \u9ebb\u91ac\u6dbc\u9eb5<\/a><\/li>\n<li id=\"menu-item-9295\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9295\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9288\">\u904a\u5b50\u60c5: \u8001\u5be6\u4eba<\/a><\/li>\n<li id=\"menu-item-9306\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9306\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9302\">\u73cd\u9948\u767e\u5473: \u963f\u53c3\u8766<\/a><\/li>\n<li id=\"menu-item-9307\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9307\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9300\">\u73cd\u9948\u767e\u5473: \u9999\u714e\u8150\u76ae\u5377<\/a><\/li>\n<li id=\"menu-item-9308\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9308\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9301\">\u73cd\u9948\u767e\u5473: \u8b93\u98ef\u684c\u8fd4\u6a38\u6b78\u771f<\/a><\/li>\n<li id=\"menu-item-9311\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9311\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9309\">\u73cd\u9948\u767e\u5473: \u8b1b\u98f2\u8b1b\u98df<\/a><\/li>\n<li id=\"menu-item-9327\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9327\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9317\">\u5065\u5eb7\u5bf6\u9452: \u4e0d\u8981\u76e1\u4fe1\u7db2\u4e0a\u5065\u5eb7\u77e5\u8b58<\/a><\/li>\n<li id=\"menu-item-9328\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9328\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9318\">\u5065\u5eb7\u5bf6\u9452: \u80a5\u80d6\u75c7\u7684\u5371\u5bb3\u8207\u9810\u9632<\/a><\/li>\n<li id=\"menu-item-9329\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9329\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9319\">\u5065\u5eb7\u5bf6\u9452: \u9aa8\u8cea\u758f\u9b06\u75c7<\/a><\/li>\n<li id=\"menu-item-9330\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9330\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9320\">\u5065\u5eb7\u5bf6\u9452: \u849c<\/a><\/li>\n<li id=\"menu-item-9331\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9331\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9321\">\u5065\u5eb7\u5bf6\u9452: \u725b\u6cb9\u679c<\/a><\/li>\n<li id=\"menu-item-9340\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-9340\"><a href=\"http:\/\/eu.cchc-herald.org\/?page_id=9338\">\u4e16\u754c\u98a8\u60c5\u756b: \u514b\u62c9\u79d1\u592b\u7684\u820a\u57ce   \u53ca\u5468\u908a\u540d\u52dd<\/a><\/li>\n<\/ul><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>2019\u5e7410\u6708 &nbsp; \u7b56\u5283\u8207\u64b0\u7a3f\uff1a\u6714\u65b9\u3001\u67ef\u6d25\u96f2\u3001\u5468\u5929\u99d2\u3001\u52de\u4f2f\u7965 \u8b93\u8cc0\u5efa\u594e\u81ea\u8c6a\u4e0d\u5df2\u7684\u4e16\u754c\u7b2c\u4e00\u5275\u8209\u7a76\u7adf\u6709\u591a\u5192\u5931\uff0c\u9732\u9732\u5a1c\u5a1c\u4fbf\u6709\u591a\u7121\u8f9c\u3002 \u300c\u812b\u9776\u300d\u6548\u61c9 \u9019\u662f\u57fa\u56e0\u7de8\u8f2f\u4e2d\u6982\u7387\u975e\u5e38\u9ad8\u7684\u300c\u526f\u4f5c\u7528\u300d\uff1a\u9664\u4e86\u76ee\u6a19\u57fa\u56e0\u5916\uff0c\u5c0e\u81f4\u5176\u4ed6\u8207\u76ee\u6a19\u5e8f\u5217\u4e0d\u5339\u914d\u7684\u5e8f\u5217\u88ab\u932f\u8aa4\u5207\u5272\uff0c\u5f9e\u800c\u5f15\u767c\u7121\u6cd5\u9810\u77e5\u7684\u7a81\u8b8a\u3002\u96d6\u7136Cas9\u524d\u6240\u672a\u6709\u5730\u7cbe\u6e96\uff0c\u53ef\u8fa8\u8a8d23\u500b\u9e7c\u57fa\u5e8f\u5217\uff08Nucleobase\uff0c\u907a\u50b3\u5bc6\u78bc\u57fa\u672c\u55ae\u5143\uff09\uff0c\u4f46\u4eba\u9ad4\u57fa\u56e0\u7d44\u6709\u7d0430\u5104\u500b\u9e7c\u57fa\u5c0d\uff0cCas9\u8981\u627e\u5230\u6b63\u78ba\u7684\u5e8f\u5217\u8ac7\u4f55\u5bb9\u6613\uff01\u5373\u4f7f\u5728\u7406\u60f3\u72c0\u6cc1\u4e0b\uff0cCas9\u6e96\u78ba\u526a\u958b\u76ee\u6a19DNA\uff0c\u4f46\u7d30\u80de\u9858\u4e0d\u9858\u5c07\u6b63\u78baDNA\u7247\u6bb5\u63a5\u4e0a\u53bb\u5462\uff1f \u5973\u5b30\u857e\u62c9\u5192\u96aa\u5be6\u65bd\u5be6\u9a57\u968e\u6bb5\u7684\u57fa\u56e0\u7642\u6cd5\uff0c\u662f\u56e0\u70ba\u9664\u6b64\u4ee5\u5916\u5225\u7121\u751f\u6a5f\u3002\u9732\u9732\u548c\u5a1c\u5a1c\u537b\u4e0d\u540c\uff0c\u65e2\u975e\u5fc5\u7136\u611f\u67d3\u611b\u6ecb\u75c5\uff08\u6bcd\u89aaHIV\u9670\u6027\uff09\uff0c\u4e5f\u7121\u7acb\u5373\u7684\u751f\u5b58\u5371\u96aa\uff0c\u800c\u4fee\u6539\u57fa\u56e0\u537b\u6709\u300c\u812b\u9776\u300d\u98a8\u96aa\uff01\u64da\u8cc0\u5efa\u594e\u81ea\u8ff0\u6aa2\u6e2c\u7d50\u679c\uff0c\u96d9\u80de\u80ce\u4e2d\u53ea\u4e00\u4f4d\u7684\u5169\u4efd\u76ee\u7684\u57fa\u56e0\u88ab\u6539\u8b8a\uff0c\u53e6\u4e00\u4f4d\u5247\u53ea\u6539\u4e86\u4e00\u4efd\u3002\u9019\u5c0d\u9732\u9732\u548c\u5a1c\u5a1c\u610f\u5473\u8457\u4ec0\u9ebc\uff1f\u6c92\u4eba\u53ef\u4ee5\u56de\u7b54\u3002 \u98a8\u96aa\u672a\u77e5 \u54e5\u672c\u54c8\u6839\u5927\u5b78\u4eba\u985e\u5b78\u6559\u6388Ayo Wahlberg\u8a8d\u70ba\uff0c\u76ee\u524d\u4eba\u985e\u57fa\u56e0\u7de8\u8f2f\u7684\u79d1\u5b78\u6c34\u5e73\u9084\u672a\u767c\u5c55\u5230\u9032\u884c\u690d\u5165\u80da\u80ce\u57fa\u56e0\u7de8\u8f2f\u7684\u5730\u6b65\u3002\u502b\u6566\u5927\u5b78\u4eba\u985e\u907a\u50b3\u5b78\u5bb6Yalda Jamshidi\u5247\u8868\u793a\uff0c\u91ab\u5b78\u754c\u5c0d\u65bc\u985e\u4f3c\u5be6\u9a57\u7522\u751f\u7684\u9577\u671f\u5f71\u97ff\u77e5\u4e4b\u751a\u5c11\uff0c\u793e\u6703\u61c9\u8a72\u4ed4\u7d30\u8003\u616e\u5982\u4f55\u627f\u64d4\u65b0\u7642\u6cd5\u5e36\u4f86\u7684\u98a8\u96aa\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u53ef\u80fd\u5f71\u97ff\u5f8c\u4ee3\u7684\u6cbb\u7642\u3002 CCR5\u57fa\u56e0\u96d6\u662fHIV\u611f\u67d3\u7d30\u80de\u7684\u53d7\u9ad4\uff08\u8def\u5f91\uff09\uff0c\u4f46\u5176\u651c\u5e36\u7684\u907a\u50b3\u6307\u4ee4\u53ef\u4f7f\u4eba\u985e\u62b5\u6297\u5176\u4ed6\u75c5\u6bd2\u611f\u67d3\uff0c\u5c24\u5176\u662f\u6d41\u611f\u3002\u300a\u8907\u96dc\u75be\u75c5\u907a\u50b3\u5b78(Genetics of Complex Disease)\u300b\u4e00\u66f8\u5373\u6307\u51fa\uff0cCCR5\u5728\u5c0d\u897f\u5c3c\u7f85\u6cb3\u75c5\u6bd2\u611f\u67d3\u7684\u514d\u75ab\u53cd\u61c9\u4e2d\u626e\u6f14\u91cd\u8981\u7684\u89d2\u8272\u3002 \u52a0\u5dde\u5927\u5b78\u4f2f\u514b\u5229\u5206\u6821\u7814\u7a76\u4e86\u82f1\u570b\u8fd141\u842c\u4eba\u7684\u6a23\u672c\uff0c\u5831\u544a\u767c\u8868\u5728\u300c\u81ea\u7136\u91ab\u5b78(Nature Medicine)\u300d\u671f\u520a\uff1a\u9ad4\u5167\u6709CCR5\u8b8a\u7570\u57fa\u56e0\u7684\u4eba\uff0c\u572878\u6b72\u524d\u6b7b\u4ea1\u7684\u53ef\u80fd\u6027\u9ad8\u65bc\u5e38\u4eba20\uff05\uff1b\u6b7b\u56e0\u5c31\u662f\u975e\u5e38\u5e73\u51e1\u7684\u611f\u5192\u985e\u75be\u75c5\uff0c\u53ef\u80fd\u5728\u611f\u67d3\u897f\u5c3c\u7f85\u6cb3\u75c5\u6bd2\u5f8c\u51fa\u73fe\u66f4\u56b4\u91cd\u7684\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\u3002\u4e3b\u6301\u7814\u7a76\u7684Rasmus Nielsen\u6559\u6388\u8aaa\uff1a\u300c\u5982\u6b64\u7684\u57fa\u56e0\u6539\u8b8a\uff0c\u53ef\u80fd\u4e26\u4e0d\u662f\u4eba\u60f3\u8981\u7684\u3002\u300d \u6548\u679c\u672a\u660e \u6709\u5c08\u5bb6\u5f62\u5bb9\uff0c\u901a\u904eCCR5\u57fa\u56e0\u7de8\u8f2f\u8b93\u9732\u9732\u5a1c\u5a1c\u514d\u75ab\u611b\u6ecb\u75c5\u7684\u505a\u6cd5\uff0c\u7121\u7570\u65bc\u300c\u5927\u7832\u6253\u9ebb\u96c0\u300d\u3002\u9996\u5148\uff0c\u9810\u9632HIV\u6709\u66f4\u7c21\u4fbf\u3001\u66f4\u5b89\u5168\u7684\u65b9\u5f0f\u3002\u611b\u6ecb\u75c5\u6297\u75c5\u6bd2\u85e5\u7269\u6cbb\u7642\u5341\u5206\u6210\u719f\uff0c\u75c5\u4eba\u6bcf\u5929\u50c5\u9700\u670d\u7528\u4e00\u7c92\u85e5\u7269\uff0c\u4fbf\u53ef\u4ee5\u628a\u75c5\u6bd2\u58d3\u5236\u5728\u6975\u4f4e\u6c34\u5e73\uff0c\u5ef6\u9577\u58fd\u547d\u905450\u5e74\u3002\u502b\u6566\u5e1d\u570b\u5b78\u9662\u5e79\u7d30\u80de\u7814\u7a76\u5c08\u5bb6Dusko Ilic\u4e5f\u8868\u793a\uff0c\u5982\u679c\u611b\u6ecb\u75c5\u60a3\u8005\u4ee5\u85e5\u7269\u63a7\u5236\u75c5\u60c5\uff0c\u5e7e\u4e4e\u4e0d\u53ef\u80fd\u6703\u628a\u75c5\u6bd2\u50b3\u67d3\u7d66\u4e0b\u4e00\u4ee3\u3002 \u5176\u6b21\uff0c\u7528CRISPR\/Cas9\u6280\u8853\u8b8a\u7570CCR5\u57fa\u56e0\uff0c\u662f\u8b93\u514d\u75ab\u7d30\u80de\u62ab\u4e0a\u300c\u96b1\u8eab\u8863\u300d\uff0c\u4ee4\u75c5\u6bd2\u7121\u6cd5\u627e\u5230\u653b\u64ca\u76ee\u6a19\uff0c\u4e5f\u5c31\u4e0d\u80fd\u4fb5\u5165\u7d30\u80de\u589e\u6b96\uff0c\u6700\u7d42\u53cd\u88ab\u4eba\u9ad4\u5fb9\u5e95\u6e05\u9664\u2026\u2026\u4f46\u662f\uff0c\u4eba\u70ba\u8b8a\u7570\u7684CCR5\u57fa\u56e0\uff0c\u8207\u6cbb\u7652\u4e86\u300c\u67cf\u6797\u75c5\u4eba\u300d\u7684\u81ea\u7136\u57fa\u56e0\u7f3a\u9677CCR5-\u039432\uff0c\u662f\u5426\u529f\u6548\u76f8\u540c\u537b\u4ecd\u662f\u672a\u77e5\u6578\u3002 \u518d\u8005\uff0cCCR5\u53ea\u662fR5\u578bHIV\u75c5\u6bd2\u7684\u53d7\u9ad4\u86cb\u767d\uff1bHIV\u75c5\u6bd2\u9084\u6709X4\u578b\uff0c\u6240\u5c0d\u61c9\u7684\u611f\u67d3\u8def\u5f91\u662fCXCR4\u53d7\u9ad4\u86cb\u767d\u3002\u4e5f\u5c31\u662f\u8aaa\uff0c\u5373\u4f7f\u9732\u9732\u548c\u5a1c\u5a1c\u7684CCR5\u57fa\u56e0\u7de8\u8f2f\u5b8c\u5168\u6210\u529f\uff0c\u4e5f\u53ea\u514d\u75ab\u4f86\u81eaR5\u7684\u611f\u67d3\uff0c\u5c0dX4\u7684\u5165\u4fb5\u4ecd\u7121\u80fd\u70ba\u529b\uff01\u5f9e\u9019\u500b\u610f\u7fa9\u4e0a\u8aaa\uff0c\u5979\u5011\u4e26\u4e0d\u662f\u771f\u6b63\u7684\u611b\u6ecb\u75c5\u5b8c\u5168\u514d\u75ab\u8005\u3002 \u9732\u9732\u548c\u5a1c\u5a1c\u7684\u7236\u6bcd\u53ef\u77e5\u4ed6\u5011\u7684\u6c7a\u5b9a\uff0c\u5c07\u8b93\u5b69\u5b50\u64d4\u7576\u4e86\u591a\u9ebc\u5927\u7684\u5065\u5eb7\u4e43\u81f3\u751f\u547d\u98a8\u96aa\uff1f \u4eba\u985e\u7684\u72c2\u5984\uff0c\u662f\u5728\u5fae\u4e0d\u8db3\u9053\u7684\u300c\u767c\u73fe\u300d\u9762\u524d\u5f97\u610f\u5fd8\u5f62\uff0c\u4ee5\u70ba\u81ea\u5df1\u7d42\u53ef\u66ff\u4ee3\u9020\u7269\u4e3b\uff0c\u537b\u4e0d\u77e5\u8b93\u81ea\u5df1\u9a30\u96f2\u99d5\u9727\u7684\u53ea\u662f\u5df4\u5225\u5854\uff08\u5984\u60f3\u901a\u5929\u7684\u4eba\u9020\u5854\uff09\u800c\u5df2\u3002<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"http:\/\/eu.cchc-herald.org\/index.php?rest_route=\/wp\/v2\/pages\/9167"}],"collection":[{"href":"http:\/\/eu.cchc-herald.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/eu.cchc-herald.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/eu.cchc-herald.org\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"http:\/\/eu.cchc-herald.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9167"}],"version-history":[{"count":3,"href":"http:\/\/eu.cchc-herald.org\/index.php?rest_route=\/wp\/v2\/pages\/9167\/revisions"}],"predecessor-version":[{"id":11145,"href":"http:\/\/eu.cchc-herald.org\/index.php?rest_route=\/wp\/v2\/pages\/9167\/revisions\/11145"}],"wp:attachment":[{"href":"http:\/\/eu.cchc-herald.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}